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KMID : 0391419940040010001
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Korean Journal of Lipidology
1994 Volume.4 No. 1 p.1 ~ p.10
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Effects of Dietary levels of w6/w3 Fatty Acids and Vitamin E on the Rat heart Mitochondrial Enzyme Activity
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Abstract
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Biomembrane system can be affected by dietary fats of which it is composed. Effects of different kinds of PUFA(linoleic acid C18:2ω6, linolenic acid C18:3ω3, EPA, DHA C20:5ω3, C22:6ω3) and α-tocopherol levels (100IU/Kg diet, 1100IU/Kg diet )
on the
rat heart mitochondrial membrane were studied. Female rats were fed 6 different experimental diets throughout the pregnancy and after birth, the same diet was given to the offsprings until 7-wks old. ① Specific activities of cyto chrome c
oxidase,
②
fatty acid compositions, and ③ vitamin E concentrations of mitochondrial membrane were measured.
Specific activities of of cytochrome c oxidase were significantly lowered in fish oil group as compared with corn oil group. this may be related to the function of cardiolipin which is known to be closely associated with cytochrome c oxidase and
contains linoleic acid(C18:2, ω6) as an essential component. Docosahexaenoic acid(DHA) was detected in the heart of all experimental groups, even in the groups fed corn oil diet which contains trace amount of precursor (C18:3, ω3) and no DHA,
suggesting the essential role of DHA in the heart.
Concentrations of vitamin E tended to decrease with the increase of peroxidatibility index of the mitochondria and this decrease was clearer when the diets were supplemented with vitamin E.
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